Mathematical virology, virus evolution, infectivity, vaccine breakthrough and antibody resistance
Third party YouTube about
our work on SARS-CoV-2
SARS-CoV-2
RBD Mutations in the US.
Jiahui Chen, Daniel R. Woldring,
Faqing Huang, Xuefei Huang,
and Guo-Wei Wei, Topological deep learning based deep mutational scanning,
Computers in Biology and Medicine, 164,
107258 (2023).
Persistent
topological Laplacian analysis of SARS-Cov-2 variants, Journal of Computational Biophysics and
Chemistry, 22, 569-587 (2023).
Emerging dominant
SARS-CoV-2 variants, Journal of Chemical Information and Modeling, 63, 335–342 (2022).
Persistent Laplacian
projected Omicron BA.4 and BA.5 to become new dominating variants, Computers in Biology and Medicine, 151, 106262, (2022).
Omicron
BA.2 (B.1.1.529.2): high potential to becoming the next dominating variant,
The Journal of Physical Chemistry Letters, 13,
3840-3849 (2022).
Artificial
intelligence design of mutation-proof COVID-19 antibody therapies, Communications in Information and Systems,
accepted, (2022).
Review
of the mechanisms of SARS-CoV-2 evolution and transmission, Chemical
Science, (2021).
Emerging vaccine-breakthrough
SARS-CoV-2 variants, ACS Infectious
Diseases, 8,
3, 546–556 (2022).
Methodology-centered review of
molecular modeling, simulation, and prediction of SARS-CoV-2, Chemical Reviews, Chemical Review, 122, 13, 11287–1136
(2022).
Mechanisms of
SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and
America, The Journal of Physical Chemistry
Letters, 12, 11850-11857 (2021).
Perspective of SARS-CoV-2 main protease inhibitors,
Journal of Medicinal Chemistry, 64, 16922-16955 (2021).
Revealing
the threat of emerging SARS-CoV-2 mutations to antibody therapies, Journal
of Molecular Biology, 433, 167155 (2021).
Vaccine-escape and fast-growing mutations in
the United Kingdom, the United States, Singapore, Spain, South Africa, and
other COVID-19-devastated countries, Genomics, 11, 2158-2170 (2021).
UMAP-assisted K-means
clustering of large-scale SARS-CoV-2 mutation datasets, Computers in
Biology and Medicine, 131, 104264 (2021).
Prediction
and mitigation of mutation threats to COVID-19 vaccines and antibody therapies,
Chemical Science, 12, 6929 - 6948 (2021).
SARS-CoV-2 becoming
more infectious as revealed by algebraic topology and deep learning,
Communications in Information and
Systems, 21(1), 31-36 (2021).
Host
immune response driving SARS-CoV-2 evolution, Viruses, 12, 1095 (2020).
Analysis of SARS-CoV-2
mutations in the United States suggests presence of four substrains
and novel variants, Communications Biology, 4, 228 (2021).
Decoding
asymptomatic COVID-19 infection and transmission, The
Journal of Physical Chemistry Letters, 11, 10007-10015 (2020).
Review of COVID-19 antibody therapies, Annual
Review of Biophysics, 50, 1-30, (2021).
Mutations
strengthened SARS-CoV-2 infectivity, Journal of Molecular Biology, 432,
5212-5226 (2020).
Mutations on COVID-19 diagnostic targets, Genomics,
112, 5204-5213 (2020).
Repositioning
of 8565 existing drugs for COVID-19, The Journal of Physical
Chemistry Letters, 11, 13, 5373–5382 (2020).
Unveiling the
molecular mechanism of SARS-CoV-2 main protease inhibition from 92 crystal
structures, Chemical
Science, 11, 12036 - 12046
(2020).
Decoding
SARS-CoV-2 transmission, evolution and ramification on COVID-19 diagnosis,
vaccine, and medicine, Journal of Chemical Information and Modeling, 60,
5853-5865 (2020).
Potentially highly potent drugs for 2019-nCoV
Machine
intelligence design of 2019-nCoV drugs